USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: DCUP_HUMAN USC-OGP 2-DE database:  DCUP_HUMAN DCUP_HUMAN General information about the entry View entry in simple text format Entry name DCUP_HUMAN Primary accession number P06132 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Uroporphyrinogen decarboxylase; Short=UPD; Short=URO-D; EC=4.1.1.37;. Gene name Name=UROD Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0721: pI=5.58; Mw=39132 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1192: pI=5.85; Mw=41038 Cross-references UniProtKB/Swiss-Prot P06132; DCUP_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DCUP_HUMAN Primary accession number P06132 Secondary accession number(s) A8K762 Q16863 Q16883 Q53YB8 Q53ZP6 Q6IB28 Q9BUZ0 Sequence was last modified on  November 1, 1997 (version 2) Annotations were last modified on  March 15, 2017 (version 196) Name and origin of the protein Description RecName: Full=Uroporphyrinogen decarboxylase; Short=UPD; Short=URO-D; EC=4.1.1.37; Gene name Name=UROD Encoded on Name=UROD Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Decarboxylase; Direct protein sequencing; Disease mutation; Heme biosynthesis; Lyase; Porphyrin biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M14016; AAA61258.1; -; mRNA EMBL X89267; CAA61540.1; -; Genomic_DNA EMBL AF047383; AAC03563.1; -; Genomic_DNA EMBL AF104421; AAD04571.1; -; mRNA EMBL AF104422; AAD04572.1; -; mRNA EMBL AF104423; AAD04573.1; -; mRNA EMBL AF104424; AAD04574.1; -; mRNA EMBL AF104425; AAD04575.1; -; mRNA EMBL AF104426; AAD04576.1; -; mRNA EMBL AF104427; AAD04577.1; -; mRNA EMBL AF104428; AAD04578.1; -; mRNA EMBL AF104429; AAD04579.1; -; mRNA EMBL AF104430; AAD04580.1; -; mRNA EMBL AF104431; AAD04581.1; -; mRNA EMBL AF104432; AAD04582.1; -; mRNA EMBL AF104433; AAD04583.1; -; mRNA EMBL AF104434; AAD04584.1; -; mRNA EMBL AF104435; AAD04585.1; -; mRNA EMBL AF104436; AAD04586.1; -; mRNA EMBL AF104437; AAD04587.1; -; mRNA EMBL AF104438; AAD04588.1; -; mRNA EMBL AF104439; AAD04589.1; -; mRNA EMBL AF104440; AAD04590.1; -; mRNA EMBL AY292986; AAP44118.1; -; Genomic_DNA EMBL BT006737; AAP35383.1; -; mRNA EMBL CR456976; CAG33257.1; -; mRNA EMBL CR542057; CAG46854.1; -; mRNA EMBL AK291877; BAF84566.1; -; mRNA EMBL AL359473; CAI16440.1; -; Genomic_DNA EMBL CH471059; EAX07007.1; -; Genomic_DNA EMBL BC001778; AAH01778.1; -; mRNA EMBL U30787; AAC50482.1; -; Genomic_DNA EMBL M60891; AAB59456.1; -; Genomic_DNA CCDS CCDS518.1; -; . PIR A24411; A24411; . PIR G02786; G02786; . RefSeq NP_000365.3; NM_000374.4; . UniGene Hs.78601; -; . PDB 1JPH; X-ray; 2.10 A; A=1-367 PDB 1JPI; X-ray; 2.30 A; A=1-367 PDB 1JPK; X-ray; 2.20 A; A=1-367 PDB 1R3Q; X-ray; 1.70 A; A=1-367 PDB 1R3R; X-ray; 1.85 A; A=1-367 PDB 1R3S; X-ray; 1.65 A; A=1-367 PDB 1R3T; X-ray; 1.70 A; A=1-367 PDB 1R3V; X-ray; 1.90 A; A=1-367 PDB 1R3W; X-ray; 1.70 A; A=1-367 PDB 1R3Y; X-ray; 1.75 A; A=1-367 PDB 1URO; X-ray; 1.80 A; A=1-367 PDB 2Q6Z; X-ray; 2.00 A; A=11-366 PDB 2Q71; X-ray; 1.90 A; A=11-366 PDB 3GVQ; X-ray; 2.10 A; A=1-367 PDB 3GVR; X-ray; 2.20 A; A=1-367 PDB 3GVV; X-ray; 2.80 A; A=1-367 PDB 3GVW; X-ray; 2.80 A; A=1-367 PDB 3GW0; X-ray; 2.00 A; A=1-367 PDB 3GW3; X-ray; 1.70 A; A=1-367 PDBsum 1JPH; -; . PDBsum 1JPI; -; . PDBsum 1JPK; -; . PDBsum 1R3Q; -; . PDBsum 1R3R; -; . PDBsum 1R3S; -; . PDBsum 1R3T; -; . PDBsum 1R3V; -; . PDBsum 1R3W; -; . PDBsum 1R3Y; -; . PDBsum 1URO; -; . PDBsum 2Q6Z; -; . PDBsum 2Q71; -; . PDBsum 3GVQ; -; . PDBsum 3GVR; -; . PDBsum 3GVV; -; . PDBsum 3GVW; -; . PDBsum 3GW0; -; . PDBsum 3GW3; -; . DisProt DP00308; -; . ProteinModelPortal P06132; -; . SMR P06132; -; . BioGrid 113235; 19; . IntAct P06132; 11; . MINT MINT-3005024; -; . STRING 9606.ENSP00000246337; -; . ChEMBL CHEMBL1681619; -; . DrugBank DB03727; Coproporphyrin I; . DrugBank DB04461; Coproporphyrin Iii; . iPTMnet P06132; -; . PhosphoSitePlus P06132; -; . BioMuta UROD; -; . DMDM 2507533; -; . OGP P06132; -; . EPD P06132; -; . MaxQB P06132; -; . PaxDb P06132; -; . PeptideAtlas P06132; -; . PRIDE P06132; -; . TopDownProteomics P06132; -; . DNASU 7389; -; . Ensembl ENST00000246337; ENSP00000246337; ENSG00000126088; . GeneID 7389; -; . KEGG hsa:7389; -; . UCSC uc001cna.3; human; . CTD 7389; -; . DisGeNET 7389; -; . GeneCards UROD; -; . GeneReviews UROD; -; . HGNC HGNC:12591; UROD; . HPA HPA027468; -; . HPA HPA028668; -; . HPA HPA030350; -; . MalaCards UROD; -; . MIM 176100; phenotype; . MIM 613521; gene; . neXtProt NX_P06132; -; . OpenTargets ENSG00000126088; -; . Orphanet 95159; Hepatoerythropoietic porphyria; . Orphanet 101330; Porphyria cutanea tarda; . PharmGKB PA37221; -; . eggNOG KOG2872; Eukaryota; . eggNOG COG0407; LUCA; . GeneTree ENSGT00390000018302; -; . HOVERGEN HBG000229; -; . InParanoid P06132; -; . KO K01599; -; . OMA EHVPVWC; -; . OrthoDB EOG091G0EUA; -; . PhylomeDB P06132; -; . TreeFam TF300744; -; . BioCyc MetaCyc:HS04993-MONOMER; -; . BRENDA 4.1.1.37; 2681; . Reactome R-HSA-189451; Heme biosynthesis; . UniPathway UPA00251; UER00321; . ChiTaRS UROD; human; . EvolutionaryTrace P06132; -; . GeneWiki Uroporphyrinogen_III_decarboxylase; -; . GenomeRNAi 7389; -; . PRO PR:P06132; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000126088; -; . CleanEx HS_UROD; -; . ExpressionAtlas P06132; baseline and differential; . Genevisible P06132; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0004853; F:uroporphyrinogen decarboxylase activity; IDA:UniProtKB; . GO GO:0006783; P:heme biosynthetic process; IC:UniProtKB; . GO GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway; . CDD cd00717; URO-D; 1; . HAMAP MF_00218; URO_D; 1; . InterPro IPR006361; Uroporphyrinogen_deCO2ase_HemE; . InterPro IPR000257; Uroporphyrinogen_deCOase; . Pfam PF01208; URO-D; 1; . TIGRFAMs TIGR01464; hemE; 1; . PROSITE PS00906; UROD_1; 1; . PROSITE PS00907; UROD_2; 1; .

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